ABSTRACT
Introduction: Cryolipolysis (CLL) is a widely employed noninvasive procedure for body fat reduction. It operates by inducing
cooling, leading to the crystallization of cytoplasmic lipids, loss of cellular integrity, and apoptosis/necrosis of adipocytes,
accompanied by local inflammation. Ongoing discussions revolve around CLL’s potential to transform white adipocytes into
brown adipocytes, potentially yielding more significant effects compared to alternative procedures.
Objective: Thus, this randomized, blinded clinical study aimed to investigate the effects of CLL on adipose tissue and elucidate
the mechanisms involved in its application and capacity for adipocyte conversion.
Methodology: Tissue samples from six patients were assessed at intervals of 45, 60, and 90 days following the application of the
CLL protocol during abdominoplasty surgeries.
Results: The samples underwent immunohistochemical analyses targeting various markers, revealing higher expression of
PPAR‐gamma, PPAR‐alpha, and UCP‐1 markers in CLL‐treated samples.
Conclusion: Therefore, the present study suggests that CLL has the ability to intervene in adipocyte conversion.